منابع مشابه
TRP channels.
The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains. A unifying theme in this group is that TRP proteins play critical roles in s...
متن کاملTRP channels and thermosensation.
Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses (sight, hearing, taste, smell and touch), touch is perhaps the most varied and least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-stand...
متن کاملTRP channels and pain.
Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation. These natural products have revealed three members of the transient receptor potential (T...
متن کاملTRP Channels and Pruritus
Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we f...
متن کاملSensing with TRP channels.
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors. The identification of the trp gene and the search for homologs in yeast, flies, worms, zebrafish and mammals has led to the discovery of a large superfamily of related cation channels, named TR...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2007
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.75.103004.142819